Properties of Collagen/Sodium Alginate Hydrogels for Bioprinting of Skin Models

3D printing technology has great potential for the reconstruction of human skin. However, reconstructed skin some differences from natural skin, largely because hydrogel used does not have appropriate biological and physical properties to allow healing regeneration. This study examines swelling, degradability, microstructure Collagen/Sodium Alginate (Col/SA) hydrogels differing compositions purposes printing. Increasing content sodium alginate causes exhibit stronger mechanical swelling properties, a faster degradation ratio, smaller pore size, less favorable properties. An optimal 1% collagen was print bi-layer in which fibroblasts keratinocytes showed improved spreading proliferation as compared other developed formulations. The Col/SA presented suitable tunability be bioink bioprinting aiming at finding applications models wound research.